P-toluenesulfonate hydrate of thiazoline compound

Details P-toluenesulfonate hydrate of thiazoline compound P-toluenesulfonate hydrate of thiazoline compound

C - Chemistry, Metallurgy

07

D

C07D 491/113 (2006.01) A61K 31/435 (2006.01) C07D 491/10 (2006.01)

Patent

CA 2262902

p-Toluenesulfonate dihydrate of the thiazoline compound of formula (1); and fibrinogen receptor antagonists comprising the same as the active ingredient. The above dihydrate exhibits an excellent antagonism against fibrinogen receptors and is easy of storage and formulation into oral drugs because of its non-hygroscopic property.

La présente invention concerne un composé p-toluènesulfonate dihydraté de thiazoline représenté par la formule générale (1) ainsi que des antagonistes des récepteurs des fibrinogènes dont ce composé est le principe actif. Ce composé dihydraté, qui fait preuve d'un excellent antagonisme contre les récepteurs des fibrinogènes, est facile à conserver et entre aussi facilement dans la formule de médicaments d'administration orale en raison de sa propriété non hygroscopique.

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