P0438 - a new calcium-regulated promoter

Details P0438 - a new calcium-regulated promoter P0438 - a new calcium-regulated promoter

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) C07H 21/04 (2006.01) C12N 1/21 (2006.01) C12N 9/02 (2006.01) C12N 9/12 (2006.01) C12N 15/76 (2006.01)

Patent

CA 2084351

There is disclosed a new calcium-regulated promoter to be used for increasing production of extracellular enzymes, or heterologous polypeptides, a recombinant vector that includes the DNA sequence of the promoter operatively linked to a DNA encoding said enzyme or polypeptide and a host organism transformed with the recombinant vector that includes the promoter operatively linked to the DNA encoding said enzyme or polypeptide. The present invention further relates to Streptomyces expression systems and methods for expressing foreign DNA sequences in Streptomyces and for secreting to the surrounding medium polypeptides and proteins coded for by those foreign DNA sequences.

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