G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/68 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) G01N 33/50 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2387731
The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.
La présente invention concerne des polypeptides, des acides nucléiques et des molécules apparentées qui ont une incidence sur le cycle cellulaire ou qui sont en rapport avec ledit cycle. L'invention concerne également des vecteurs et des cellules hôtes renfermant lesdites séquences d'acides nucléiques, des molécules polypeptidiques chimères comprenant les polypeptides selon l'invention fusionnées à des séquences polypeptidiques hétérologues, des anticorps qui se lient aux polypeptides de l'invention, ainsi que des méthodes d'obtention desdits polypeptides. Cette invention concerne également des méthodes d'identification de compositions qui induisent une bioactivité du cycle cellulaire ainsi que l'utilisation de ces méthodes pour le diagnostic et le traitement de la maladie.
Huang Betty
Luo Ying
Yu Peiwen
Rigel Pharmaceuticals Inc.
Smart & Biggar
LandOfFree
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