P18abrp gene and p18abrp protein, and novel gene/protein...

Details P18abrp gene and p18abrp protein, and novel gene/protein... P18abrp gene and p18abrp protein, and novel gene/protein...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61P 25/28 (2006.01) C07K 14/47 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2432937

The present invention provides a p18A.beta.rP gene having novel functions of promoting cell death, and its product, a p18A.beta.rP protein. The present invention also provides screening systems to which these are applied, cell-death promoting or suppressing substances obtainable by the screening system, and pharmaceutical compositions for the treatment and/or prophylaxis of diseases containing them.

L'invention porte sur le gène p18A beta rP présentant de nouvelles propriétés de promotion, entre autres, de la mort cellulaire et sur la protéine p18A beta rP qui est le produit du gène susmentionné. L'invention se rapporte aussi à un système de criblage fondé sur l'utilisation du gène et de la protéine, à une substance obtenue au moyen du système de criblage et qui promeut ou inhibe la mort cellulaire, ainsi qu'à des compositions médicinales contenant ledit gène et ladite protéine et permettant de traiter/prévenir certaines maladies.

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