P27 prevents cellular migration

A - Human Necessities – 61 – K

Patent

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A61K 31/00 (2006.01) A01N 37/18 (2006.01) A01N 61/00 (2006.01) A61K 31/395 (2006.01) A61K 38/43 (2006.01) A61K 38/51 (2006.01) A61K 38/52 (2006.01) A61K 38/53 (2006.01) A61K 38/54 (2006.01) C07K 14/47 (2006.01) C12Q 1/00 (2006.01) C12Q 1/48 (2006.01) G01N 33/48 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01) G01N 33/567 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2434696

This invention provides methods of preventing cellular migration and of treating cardiovascular diseases and tumor metastasis by increasing cyclindependent kinase inhibitor p27 activity, and methods of identifying chemical compounds for use in such treatments.

L'invention concerne des méthodes de prévention de la migration cellulaire et de traitement de maladies cardiovasculaires et de métastases tumorales par augmentation de l'activité de l'inhibiteur de kinase P27 dépendant de la cycline. L'invention concerne également des procédés d'identification de composés chimiques à utiliser dans ces traitements.

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