P2x7 receptor antagonists and methods of use

Details P2x7 receptor antagonists and methods of use P2x7 receptor antagonists and methods of use

C - Chemistry, Metallurgy

07

D

C07D 249/06 (2006.01) A61K 31/4192 (2006.01) A61K 31/4196 (2006.01) A61P 25/00 (2006.01) C07D 249/08 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/04 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2627114

The invention is directed to compounds that are P2X7 antagonist and have the formula (I) or (II) or a pharmaceutically acceptable salt, prodrug, salt of a prodrug or a combination thereof, wherein R1, R2, and R3 are defined in the specification. The invention is also directed to a method of selectively inhibiting P2X7 activity comprising administering to a patient in need of such treatment a therapeutically effective amount of a compound of formula (III), (IV) or (V) wherein R6, R7, R8, R9, R10, and R11 are defined in the specification.

L'invention concerne des composés qui sont des antagonistes des P2X7 et représentés par la formule (I) ou (II), ou un sel, un promédicament, un sel d'un promédicament ou une combinaison de ces derniers pharmaceutiquement acceptables. Dans lesdites formules, R1, R2 et R3 sont tels que définis dans la description. L'invention concerne également une méthode d'inhibition sélective de l'activité des P2X7 consistant à administrer à un patient en attente d'un tel traitement une quantité thérapeutiquement efficace d'un composé représenté par les formules (III), (IV) ou (V), dans lesquelles R6, R7, R8, R9, R10 et R11 sont tels que définis dans la description.

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