C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 1/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/06 (2006.01) C12N 5/16 (2006.01) C12P 21/06 (2006.01) G01N 33/53 (2006.01) G01N 33/74 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2395416
The present invention includes a novel subtype of the P2-purinergic receptor, referred to as the P2Y12 receptor. This receptor is expressed selectively in the platelets and brain, and couples to a pertussis toxin-sensitive G protein (Gi). Nucleic acids encoding the receptor and associated screening and therapeutic methods are also disclosed.
L'invention concerne un nouveau sous-type du récepteur P2 purinergique, désigné récepteur P2Y12. Ce récepteur est exprimé de façon sélective dans les plaquettes et le cerveau et se lie à une protéine G sensible à la toxine de pertussis (Gi). L'invention concerne également des acides nucléiques codant ce récepteur, ainsi que des procédés associés de criblage et de traitement.
Conley Pamela B.
Hollopeter Gunther
Jantzen Hans-Michael
Julius David Jay
Ramakrishnan-Dubridge Vanitha
Conley Pamela B.
Deeth Williams Wall Llp
Hollopeter Gunther
Jantzen Hans-Michael
Julius David Jay
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