P2y6 receptor agonists for treating lung diseases

Details P2y6 receptor agonists for treating lung diseases P2y6 receptor agonists for treating lung diseases

A - Human Necessities

61

K

A61K 31/7084 (2006.01) A61K 31/7064 (2006.01) A61P 11/10 (2006.01)

Patent

CA 2613326

This invention is directed to a method of enhancing or facilitating the clearance of the lung mucus secretions in a subject. This invention is also directed to a method of facilitating the hydration of the lung mucus secretions in a subject. This invention is further directed to a method of preventing or treating diseases or conditions associated with impaired lung or airway function in a human or other mammal. The method comprises administering to a subject a pharmaceutical composition comprising a therapeutic effective amount of P2Y6 receptor agonist compound, wherein said amount is effective to activate the P2Y6 receptors on the luminal surface of lung epithelia. The P2Y6 receptor agonist compounds useful for this invention include mononucleoside 5'- diphosphates, dinucleoside monophosphate, dinucleoside diphosphates, or dinucleoside triphosphates of general Formula (I), or salts, solvates, hydrates thereof.

L'invention concerne un procédé destiné à améliorer ou faciliter l'élimination des sécrétions des muqueuses pulmonaires chez un patient. L'invention concerne également un procédé destiné à faciliter l'hydratation des sécrétions des muqueuses pulmonaires chez un patient. L'invention concerne par ailleurs un procédé de prophylaxie ou de traitement de maladies associées à un dysfonctionnement pulmonaire ou respiratoire chez un humain ou un autre mammifère. Le procédé selon l'invention consiste à administrer, à un patient, une composition pharmaceutique contenant une quantité thérapeutique efficace d'un composé d'agonistes de récepteurs de P2Y6, cette quantité servant à activer les récepteurs de P2Y6 sur la surface luminale de l'épithélium pulmonaire. Les composés d'agonistes de récepteurs de P2Y6 selon l'invention contiennent des mononucléosides 5'-diphosphates, des dinucléosides diphosphates ou des dinucléosides triphosphates représentés par la formule (I) ou des sels, solvates ou hydrates de ceux-ci.

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