P38 kinase inhibiting agents

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 417/14 (2006.01) A61K 31/433 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2759269

Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: Formula (I); are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of asthma, COPD, ARDS, rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.

La présente invention a pour objet des composés décrits par la formule chimique (I) ou leurs sels pharmaceutiquement acceptables : la Formule (I) ; qui sont des inhibiteurs de la p38 et sont utiles dans le traitement d'une inflammation comme dans le traitement de l'asthme, de la COPD, de l'ARDS, de l'arthrite rhumatoïde, de la spondylite rhumatoïde, de l'ostéoarthrite, de l'arthrite goutteuse et d'autres états arthritiques ; des articulations enflammées, de l'eczéma, du psoriasis ou d'autres états inflammatoires de la peau tels que l'érythème solaire ; des états inflammatoires de l'il comprenant la conjonctivite ; le pyrosis, la douleur et d'autres états associés à une inflammation.

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