P38 kinase inhibiting agents

Details P38 kinase inhibiting agents P38 kinase inhibiting agents

C - Chemistry, Metallurgy

07

D

C07D 455/02 (2006.01) A61K 31/4375 (2006.01) A61K 31/502 (2006.01) A61P 19/02 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2631794

Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: (I) are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.

La présente invention concerne des composés décrits par la formule chimique (I) ou des sels pharmaceutiquement acceptables de ceux-ci : (I) qui sont des inhibiteurs de p38 et sont utiles dans le traitement de l'inflammation tel que le traitement de la polyarthrite rhumatoïde, la spondylarthrite ankylosante, l'arthrose, l'arthrite goutteuse et d'autres conditions arthritiques ; les articulations enflammées, l'eczéma, le psoriasis ou d'autres conditions inflammatoires de la peau telles que l'érythème solaire ; les conditions inflammatoires oculaires comprenant la conjonctivite ; le pyrosis, la douleur et d'autres conditions associées à l'inflammation.

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