P38 kinase inhibitor compositions and methods of use

Details P38 kinase inhibitor compositions and methods of use P38 kinase inhibitor compositions and methods of use

A - Human Necessities

01

N

A01N 43/40 (2006.01) A01N 43/50 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01)

Patent

CA 2535980

Methods of treating an individual who has been identified as having been infected with HIV are disclosed. Methods of treating an individual who is suspected of having been exposed to HIV are disclosed. Some methods disclosed comprise the step of administering to the individual an amount of a p38 inhibitor effective to inhibit FasL expression. Some methods disclosed comprise the step of administering to the individual an amount of a p38 inhibitor effective to inhibit HIV replication. Some methods disclosed comprise the step of administering to the individual an amount of a p38 inhibitor effective to inhibit HIV replication without inhibiting T cell activation. Some methods disclosed comprise administering to the individual one or more other anti-HIV compounds in combination with a p38 inhibitor. Methods of identifying compounds that inhibit Nef mediated upregulation of FasL expression are disclosed. Methods of identifying compounds that inhibit the p38 pathway are disclosed.

L'invention concerne des méthodes de traitement d'une personne ayant été identifiée comme ayant été infectée par le VIH ainsi que des méthodes de traitement d'une personne suspectée d'avoir été exposée au VIH. Certaines méthodes de l'invention consistent à administrer à la personne une quantité d'un inhibiteur p38 efficace pour inhiber l'expression de FasL. Certaines méthodes consistent à administrer à la personne une quantité d'inhibiteur p38 efficace pour inhiber la réplication du VIH. Certaines méthodes consistent à administrer à la personne une quantité de p38 efficace pour inhiber la réplication de VIH sans inhiber l'activation des cellules T. Certaines méthodes consistent à administrer à la personne un ou plusieurs composés anti-HIV combinés à un inhibiteur de p38. Des méthodes d'identification de composés qui inhibent la régulation à la hausse à médiation Nef de l'expression de FasL sont également décrites ainsi que des méthodes d'identification de composés qui inhibent la voie de p38.

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