P38 map kinase inhibitors

Details P38 map kinase inhibitors P38 map kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/415 (2006.01) A61P 11/00 (2006.01) A61P 29/00 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2746354

The present disclosure relates to compounds of formula (I): which are inhibitors of p38 mitogen-activated protein kinase enzymes,particularly the alpha and gamma kinase sub-types thereof, and their use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, such as COPD

Cette invention concerne des composés de formule (I) : qui sont des inhibiteurs de protéine kinase activée par le mitogène p38, en particulier de sous-types alpha et gamma kinase, et leurs utilisations thérapeutiques ainsi que des de compositions pharmaceutiques utilisées, en particulier pour le traitement de maladies inflammatoires, notamment du poumon tels que les broncho-pneumopathies chroniques obstructives du poumon (BPCO).

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