P38 map kinase inhibitors and methods for using the same

Details P38 map kinase inhibitors and methods for using the same P38 map kinase inhibitors and methods for using the same

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 11/00 (2006.01)

Patent

CA 2620105

Compounds of the formula (Ia) or (Ib) wherein X and Y are N or one of X and Y is N and the other is CRg, and A, D, E, G, W, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the subject compounds and methods of using the compounds for treatment of p38 MAP kinase-mediated diseases.

L'invention concerne des composés de formule Ia ou Ib. Dans cette formule, X et Y désignent N ou un élément parmi X et Y désigne N et l'autre désigne CRg, et A, D, E, G, W, R1, R2, R3, R4 et R5 sont définis dans la description. L'invention concerne des méthodes de fabrication des composés susmentionnés ainsi que des méthodes d'utilisation de ces composés pour traiter des maladies médiées par la MAP-kinase p38.

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