P38 map kinase inhibitors and methods for using the same

Details P38 map kinase inhibitors and methods for using the same P38 map kinase inhibitors and methods for using the same

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 11/00 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2620106

Compounds of formula Ia, Ib, Ic, Id, Ie, If, Ig or Ih: wherein X and Y are nitrogen or one of X and Y is nitrogen and the other is CRg, and W, D, E, R4, R5, R6 and Rg are as defined herein. Also disclosed are methods of making the subject compounds and methods of using the compounds in the treatment of p38 MAP kinase- mediated diseases.

L'invention concerne des composés représentés par les formules Ia, Ib, Ic, Id, Ie, If, Ig ou Ih, dans lesquelles X et Y représentent azote ou l'un parmi X et Y représente azote et l'autre représente CRg, et W, D, E, R4, R5, R6 et Rg sont tels que définis dans la description. L'invention concerne également des procédés de préparation des composés de l'invention ainsi que des procédés d'utilisation des composés dans le traitement de maladies médiées par les p38 MAP kinases.

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