P38map kinase inhibitor

Details P38map kinase inhibitor P38map kinase inhibitor

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/415 (2006.01) A61P 11/00 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2754609

The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, including all stereoisomers and tautomers, which is an inhibitor of p38 mitogen- activated protein kinase enzymes(referred to herein as p38 MAP kinase inhibitors), particularly the alpha and gamma kinase sub-types thereof, and itsuse in therapy, including in pharmaceu-tical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, such as COPD.

La présente invention porte sur un composé de formule (I) : ou sur un sel pharmaceutiquement acceptable de celui-ci, comprenant l'ensemble des stéréoisomères et tautomères, qui est un inhibiteur des enzymes kinases p38 de protéines activées par le mitogène (désigné présentement comme inhibiteur de p38 MAP kinase), en particulier de leurs sous-types alpha et gamma kinase, et sur son utilisation en thérapie, comprenant des compositions pharmaceutiques, notamment dans le traitement de maladies inflammatoires, comprenant des maladies inflammatoires du poumon, telles qu'une maladie pulmonaire obstructive chronique (COPD).

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