P40 homodimer of interleukin-12

Details P40 homodimer of interleukin-12 P40 homodimer of interleukin-12

C - Chemistry, Metallurgy

07

K

C07K 14/54 (2006.01) A61K 38/20 (2006.01) A61P 37/02 (2006.01) C07K 1/22 (2006.01) C12N 15/24 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2125763

The present invention is directed towards a protein comprising two p40 subunits of interleukin-12 which are associated together, preferably by at least one disulfide bond, having a molecular weight of about 80 kDa. The 80 kDa p40 homodimer acts as an interleukin-12 receptor antagonist. The preferred p40 subunit is that of SEQ ID NO:1.

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