P4has as modifiers of the igfr pathway and methods of use

Details P4has as modifiers of the igfr pathway and methods of use P4has as modifiers of the igfr pathway and methods of use

G - Physics

01

N

G01N 33/53 (2006.01) C07K 5/00 (2006.01) C07K 14/00 (2006.01)

Patent

CA 2567982

Human P4HA genes are identified as modulators of the IGFR pathway, and thus are therapeutic targets for disorders associated with defective IGFR function. Methods for identifying modulators of IGFR, comprising screening for agents that modulate the activity of P4HA are provided.

Les gènes humains P4HA sont identifiés comme modulateurs de voie d'accès de l'IGFR, et sont ainsi les cibles thérapeutiques pour les troubles associés à la fonction déficiente de l'IGFR (facteur de croissance de substances apparentées à l'insuline). Des méthodes sont fournies pour identifier les modulateurs de l'IGFR, comprenant le filtrage pour les agents qui modulent l'activité du P4HA.

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