P53-binding polypeptides and polynucleotides encoding same

Details P53-binding polypeptides and polynucleotides encoding same P53-binding polypeptides and polynucleotides encoding same

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) C07K 14/47 (2006.01) C07K 14/82 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) G01N 33/50 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2177074

The invention provides mammalian polypeptides which bind wild-type and/or mutant mammalian p53 proteins, polynucleotides encoding such polypeptides, screening assays for drug development employing such polypeptides and polynucleotides, immunological and other reagents for diagnostic, therapeutic, and research applications.

L'invention se rapporte à des polypeptides mammaliens qui fixent les protéines mammaliennes p53 de phénotype sauvage et/ou mutantes, à des polynucléotides codant ces polypeptides, à des méthodes de criblage pour la mise au point de médicaments, à des réactifs immunologiques et autres s'appliquant à des procédés de diagnostic, thérapeutiques et à la recherche.

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