P53 protein variants and therapeutical uses thereof

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/62 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/035 (2006.01) C07K 14/82 (2006.01) C07K 16/32 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) C12N 15/13 (2006.01) C12N 15/38 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2224468

This invention concerns proteins derived from the product of the p53 tumour suppressor gene, with improved functions for therapeutic use. It concerns, advantageously, proteins with improved tumor suppression and apoptosis induction functions, particularly in pathological proliferation contexts in which the wild-type p53 is inactivated. It also concerns nucleic acids coding for the vector molecules containing them, and their therapeutic uses, in particular gene therapy.

La présente invention concerne des protéines dérivées du produit du gène suppresseur de tumeurs p53, possédant des fonctions améliorées en vue dune utilisation thérapeutique. Elle concerne avantageusement des protéines possédant des fonctions suppresseur de tumeurs et inducteur de mort cellulaire programmée améliorées, plus particulièrement dans des contextes pathologiques de prolifération dans lesquels la protéine p53 de type sauvage est inactivée. Elle concerne également les acides nucléiques codant pour ces molécules vecteurs les contenant et leurs utilisations thérapeutiques, notamment en thérapie génique.

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