P53 treatment of papillomavirus and carcinogen-transformed...

A - Human Necessities – 61 – K

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A61K 48/00 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2511535

Methods for the prevention, suppression, and inhibition of growth of a papilloma-virus transformed cell in a hyperplastic lesion using a topically applied p53 expression cassette are disclosed. In addition, there are provided pharmaceutical preparations of a p53 expression cassette suitable for topical delivery to a papillomavirus-transformed cell in a hyperplastic lesion.

L'invention concerne des méthodes de prévention, de suppression et d'inhibition de la croissance d'une cellule transformée par le virus de papillome dans une lésion hyperplastique utilisant une cassette d'expression p53 appliquée de manière topique. Par ailleurs, on prévoit des préparations pharmaceutiques d'une cassette d'expression p53 se prêtant à une administration topique dans une cellule transformée par le virus de papillome dans une lésion hyperplastique.

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