P53 wild-type as biomarker for the treatment with mtor...

Details P53 wild-type as biomarker for the treatment with mtor... P53 wild-type as biomarker for the treatment with mtor...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2555542

Provided are biomarkers for determining the sensitivity of proliferative diseases such as cancer to therapeutic agents, in particular mTOR inhibitors in combination with a cytotoxic agent, in particular a cytotoxic agent which damages or affects the integrity of DNA.

La présente invention concerne des biomarqueurs conçus pour déterminer la sensibilité de maladies prolifératives, telles que le cancer, à des agents thérapeutiques, notamment à des inhibiteurs de mTOR combinés à un agent cytotoxique, en particulier un agent cytotoxique qui endommage ou affecte l'intégrité de l'ADN.

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