C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) C07K 16/40 (2006.01) C12N 9/12 (2006.01) C12Q 1/48 (2006.01)
Patent
CA 2148898
The p54 Stress-Activated Protein Kinases (SAPKs) are members of a large gene family and are structurally related to the previously described mitogen-activated protein kinases (MAPKs). They are distinguished by their strong activation in response to heat shock, TNF-.alpha., IL-1- .beta., sphingomyelinases, chemical protein synthesis inhibitors, and ischemia. These kinases have potential utility in the modulation of the inflammatory response and the up-regulation of repair or protective cellular proteins following injury or chemical insult.
Avruch Joseph
Banerjee Papia
Kyriakis John M.
Woodgett James R.
Ontario Cancer Institute
Smart & Biggar
The General Hospital Corporation
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