P5crs as modifiers of the p53 pathway and methods of use

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) C12Q 1/00 (2006.01) C12Q 1/26 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01) G01N 33/74 (2006.01)

Patent

CA 2449221

Human P5CR genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of P5CR are provided.

L'invention concerne des gènes humains P5CR qui sont identifiés comme des modulateurs de la voie p53, ce qui fait d'eux des cibles thérapeutiques pour des troubles associés à un dysfonctionnement de la fonction p53. L'invention concerne des procédés d'identification de modulateurs de p53, qui consistent à effectuer un criblage d'agents modulant l'activité de P5CR.

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