Pablo, a polypeptide that interacts with bcl-xl, and uses...

Details Pablo, a polypeptide that interacts with bcl-xl, and uses... Pablo, a polypeptide that interacts with bcl-xl, and uses...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61P 25/00 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2387680

The present invention relates, at least in part, to polypeptides which include Bcl-xL binding domains, novel Bcl-xL binding domains of Pablo polypeptides, nucleic acid molecules encoding such polypeptides, and uses thereof. For example, such polypeptides and nucleic acid molecules are useful in modulating apoptosis, particularly in neural cells, as well as in the treatment or prevention of disorders that can benefit from modulation of cell death.

L'invention concerne, au moins en partie, des polypeptides comprenant des domaines de liaison de Bcl-xL, de nouveaux domaines de liaison de Bcl-xL de polypeptides Pablo, des molécules d'acide nucléique codant pour ces polypeptides, et leurs utilisations. Ces polypeptides et ces molécules d'acide nucléique sont utiles pour moduler l'apoptose, en particulier dans des cellules neurales, ainsi que pour traiter ou prévenir des troubles pouvant tirer avantage de la modulation de la mort cellulaire.

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