Packaged antimicrobial medical device and method of...

A - Human Necessities – 61 – B

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A61B 17/00 (2006.01) A61B 17/04 (2006.01) A61B 17/06 (2006.01) A61K 31/075 (2006.01) A61K 31/665 (2006.01) A61L 17/00 (2006.01)

Patent

CA 2500852

An antimicrobial suture assembly comprising a containment compartment comprising one or more surfaces having an antimicrobial agent disposed thereon, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof, in an amount sufficient to substantially inhibit bacterial colonization on said containment compartment; and a suture positioned within the containment compartment, the suture comprising one or more surfaces having an antimicrobial agent disposed thereon, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof, in an amount sufficient to substantially inhibit bacterial colonization on the suture; a method for making the antimicrobial suture assembly; and a braided suture having antimicrobial properties comprising an elongate braided structure formed from a plurality of polymeric filaments, said filaments being formed from a polymeric material that is absorbable under physiological conditions, and a coating material disposed on said elongate braided structure, said coating comprising a film forming absorbable polymer, a substantially water-insoluble salt of a fatty acid and an effective amount of an antimicrobial agent selected from the group consisting of halogenated hydroxyl ethers, halogen-o-hydroxy-Biphenyl ethers, acyloxydiphenyl ethers and combinations thereof, said effective amount being sufficient to substantially inhibit microbial growth on or adjacent said suture when said suture is implanted in a patient's body.

La présente invention concerne un ensemble ligature antimicrobien comportant un compartiment de confinement dont une surface au moins a reçu une quantité suffisante d'un antimicrobien du groupe des hydroxyl-éthers halogénés, acyloxydiphényl-éthers, et certaines de leurs combinaisons, de façon à inhiber sensiblement la colonisation bactérienne sur ledit compartiment de confinement. L'invention concerne également une ligature placée à l'intérieur du compartiment de confinement et dont une surface au moins a reçu une quantité suffisante d'un antimicrobien du groupe des hydroxyl-éthers halogénés, acyloxydiphényl-éthers, et certaines de leurs combinaisons, de façon à inhiber sensiblement la colonisation bactérienne sur ladite ligature. L'invention concerne en outre un procédé d'élaboration d'un ensemble ligature antimicrobien. L'invention concerne enfin une ligature tressée aux propriétés antimicrobiennes, constituée d'une structure tressée de forme allongée, enduite d'un matériau de revêtement. La structure tressée est formée d'une pluralité de filaments polymères réalisés dans un matériau polymère absorbable sous certaines conditions physiologiques. Le matériau de revêtement est constitué d'un polymère absorbable filmogène, d'un sel d'acide gras sensiblement insoluble dans l'eau, et d'une quantité d'un antimicrobien suffisante pour inhiber sensiblement la croissance microbienne sur la ligature ou en son voisinage, lorsqu'elle est implantée dans l'anatomie d'un patient. L'antimicrobien est choisi dans le groupe des hydroxyl-éthers halogénés, halogène-o-hydroxy-diphényl-éthers, acyloxydiphényl-ethers, et certaines de leurs combinaisons.

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