A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/39 (2006.01) A61K 39/00 (2006.01) A61P 37/04 (2006.01) C07K 14/02 (2006.01) C07K 14/025 (2006.01) C07K 14/08 (2006.01) C12N 7/04 (2006.01)
Patent
CA 2492826
The invention relates to the finding that virus like particles (VLPs) can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G (CpGs). Such CpG- VLPs are dramatically more immunogenic than their CpG-free counterparts and induce enhanced B and T cell responses. The immune response against antigens optionally coupled, fused or attached otherwise to the VLPs is similarly enhanced as the immune response against the VLP itself. In addition, the T cell responses against both the VLPs and antigens are especially directed to the Thl type. Antigens attached to CpG-loaded VLPs may therefore be ....sim. ideal vaccines for prophylactic or therapeutic vaccination against allergies, tumors and other self-molecules and chronic viral diseases.
L'invention concerne la découverte que des particules de type virus (VLP) peuvent être chargées de substances immunostimulatrices, notamment des oligonucléotides d'ADN contenant des C et G non methylés (CpGs). Ces VLP CpG étant beaucoup plus immunogènes que leurs contreparties CpG-libres et induisant des réponses améliorées de lymphotcyte B et T. La réponse immunitaire contre les antigènes éventuellement couplés, fusionnés ou fixés d'une autre manière aux VLP est améliorée de façon similaire comme la réponse immunitaire contre le VLP lui-même. En outre, les réponses des lymphotcytes T contre les VLP et les antigènes sont plus particulièrement dirigées vers le type Thl. Les antigènes fixés aux VLP chargés de CPG peuvent donc être des vaccins thérapeutiques ou prophylactiques idéaux contre les allergies, les tumeurs et d'autres molécules du soi et maladies virales chroniques.
Bachmann Martin F.
Cielens Indulis
Lipowsky Gerad
Maurer Patrick
Meijerink Edwin
Cytos Biotechnology Ag
Mbm Intellectual Property Law Llp
LandOfFree
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