C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 15/863 (2006.01)
Patent
CA 2424052
The invention generally relates to recombinant polynucleotides, positive- strand RNA virus (psRNAV) recombinant expression vectors, and packaging systems. The packaging systems are based on the expression of helper functions by coinfecting recombinant poxvirus vectors comprising recombinant polynucleotides. Methods for obtaining psRNAV replicon particles using these packaging systems are disclosed. Immunogenic compositions and pharmaceutical formulations are provided that comprise replicon particles of the invention. Methods for generating an immune response or producing a pharmaceutical effect are also provided.
La présente invention concerne des polynucléotides de recombinaison, des vecteurs d'expression de recombinaison du virus d'ARN à chaîne positive (psRNAV) et des systèmes d'encapsidation. Les systèmes d'encapsidation sont basés sur l'expression de fonctions auxiliaires au moyen de la co-infection de vecteurs de poxvirus de recombinaison comprenant des polynucléotides de recombinaison. Des procédés d'obtention de particules de réplicon de psRNAV au moyen de ces systèmes d'encapsidation sont présentés, ainsi que des compositions immunogènes, des formulations pharmaceutiques renfermant les particules de réplicon selon l'invention et des procédés permettant de générer une réponse immune ou de produire un effet pharmaceutique.
Gangolli Seema S.
Kovacs Gerald R.
Kowalski Jacek
Valsilakis Nikolaos
Zamb Timothy
Ridout & Maybee Llp
Wyeth Holdings Corporation
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