C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 17/06 (2006.01) C07K 17/14 (2006.01)
Patent
CA 2061519
This invention relates to a packing for chromatography whereby a low molecular weight substance contained in biological samples can be analyzed directly with a high-level of accuracy without any pretreatment. In the packing of the present invention a protein such as avidin or ovomucoid is bound to the support via a straight or branched spacer optionally having a functional group such as a cyano group. Given that enantiomers interact differentially with proteins, a substance can thereby be separated into its optical isomers. Furthermore, a purification column packed with said packing is disclosed. According to the present invention, a low molecular weight substance can be directly and accurately analyzed without requiring any pretreatment for the purpose of removing biological macromolecules. When the packing of the present invention is employed in the purification column, the time required for the pretreatment can be shortened.
Asakawa Naoki
Oda Yoshiya
Sato Tadashi
Yoshida Yutaka
Eisai Co. Ltd.
Eisai R&d Management Co. Ltd.
G. Ronald Bell & Associates
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