C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/210, 260/239
C07D 495/14 (2006.01) A61K 31/55 (2006.01)
Patent
CA 1309093
ABSTRACT 1. This invention relates to a thienotriazolodiazepine compound of the formula: Image wherein Ar is pyridyl, phenyl or phenyl substituted by one to three substituents optionally selected from the group consisting of halogen, hydroxy, trifluoromethyl, straight or branched chain alkyl having 1 to 5 carbon atoms and straight or branched chain alkoxy having 1 to 5 carbon atoms, A is alkylene having 1 to 8 carbon atoms or alkylene having 1 to 8 carbon atoms substituted by straight or branched chain alkyl having 1 to 5 carbon atoms, R1 is hydrogen or straight or branched chain alkyl having 1 to 5 carbon atoms, R2 and R3 are the same or different and each is hydrogen, trifluoro- methyl or straight or branched chain alkyl having 1 to 5 carbon atoms, and R4, R5 and R6 are the same or different and each is hydrogen, halogen, hydroxy, trifluoromethyl, straight or branched chain alkyl having 1 to 8 carbon atoms, straight or branched chain alkyl having 1 to 8 carbon atoms substi- tuted by trifluoromethyl, straight or branched chain alkoxy having 1 to 8 carbon atoms, phenyl, phenoxy, aralkyl, aralkyloxy, or phenyl, phenoxy, aralkyl or aralkyloxy substituted by one to three substituents optionally selected from the group consisting of halogen, hydroxy, straight or branched chain alkyl having 1 to 5 carbon atoms, trifluoro- methyl and straight or branched chain alkoxy having 1 to 5 carbon atoms on the aromatic ring, and pharmaceutically acceptable acid addition salts thereof. These compounds exhibit PAF-antagonistic activity and are useful for the prevention or treatment of various PAF-induced diseases.
560928
Abe Masao
Moriwaki Minoru
Tahara Tetsuya
Yuasa Shuji
Riches Mckenzie & Herbert Llp
Welfide Corporation
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