C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 35/14 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2341642
PAGE-4 is a gene preferentially expressed in normal male and female reproductive tissues, prostate, testis, fallopian tube, uterus and placenta, as well as in prostate cancer, testicular cancer and uterine cancer. This expression pattern makes it a target for diagnosis and for vaccine based therapy of neoplasms of prostate, testis and uterus. The invention provides immunogenic compositions comprising PAGE-4 protein or immunogenic peptides thereof, methods of inhibiting the growth of malignant cells expressing PAGE- 4, and methods of inducing an enhanced immune response to PAGE-4-expressing cancers.
PAGE-4 est un gène exprimé de préférence dans les tissus reproducteurs féminins et masculins normaux, dans la prostate, les testicules, les trompes de Fallope, l'utérus et le placenta ainsi que dans les cancers de la prostate, des testicules et de l'utérus. Ce motif d'expression utilise ce gène comme cible pour la thérapie des néoplasmes de la prostate, des testicules et de l'utérus basée sur le diagnostic et la vaccination. L'invention concerne des compositions immunogènes contenant la protéine PAGE-4 ou ses peptides immunogènes. L'invention concerne également des procédés d'inhibition de la croissance des cellules malignes exprimant PAGE-4 et des procédés d'induction d'une réponse immunitaire améliorée aux cancers exprimant PAGE-4.
Brinkmann Ulrich
Lee Byungkook
Pastan Ira
Vasmatzis George
Fetherstonhaugh & Co.
The Government Of The United States Of America As Represented By
LandOfFree
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