Paget disease of bone

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/11 (2006.01) A01K 67/027 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2456037

Mutations in the atypical protein kinase C-interacting protein p62/ sequestosome 1 (p62/SQSTM1) causing Paget disease of bone are described. Methods of detecting and treating Paget disease of bone are also disclosed.

L'invention concerne des mutations dans p62/ sequestosome 1 (p62/SQSTM1) de la protéine à interaction C de la protéine kinase atypique, qui cause la maladie osseuse de Paget. Elle concerne aussi des procédés pour traiter la maladie osseuse de Paget.

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