Pai-1 binding modulators for the treatment of ocular disorders

Details Pai-1 binding modulators for the treatment of ocular disorders Pai-1 binding modulators for the treatment of ocular disorders

A - Human Necessities

61

K

A61K 31/122 (2006.01) A61K 31/19 (2006.01) A61K 31/41 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2666316

The invention concerns in one embodiment a method for treating glaucoma or elevated IOP in a patient comprising administering to the patient an effective amount of a composition comprising an agent that modulates PAI-1 binding to vitronectin. In another embodiment, the invention concerns a method of manufacturing a compound to be used as a treatment for glaucoma or elevated IOP comprising providing a candidate substance suspected of modulating PAI-1 binding, selecting the compound by assessing the ability of the candidate substance to decrease the amount of active PAI-1 in the trabecular meshwork of a subject suffering from glaucoma or elevated PAI-1, and manufacturing the selected compound.

Dans un mode de réalisation, l'invention concerne une méthode de traitement du glaucome ou d'une tension intraoculaire élevée chez un patient, consistant à administrer au patient une quantité efficace d'une composition contenant un agent qui module la liaison de PAI-1 à la vitronectine. Dans un autre mode de réalisation, l'invention concerne un procédé de fabrication d'un composé destiné à être utilisé dans le traitement du glaucome ou d'une tension intraoculaire élevée, consistant à obtenir une substance candidate supposée moduler la liaison de PAI-1, à choisir le composé en fonction de la capacité de la substance candidate à réduire la quantité de PAI-1 actif dans le trabéculum cornéoscléral d'un patient souffrant d'un glaucome ou d'une tension intraoculaire élevée, et à fabriquer le composé sélectionné.

Affiliated with

Also associated with

Rating

Pai-1 binding modulators for the treatment of ocular disorders does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pai-1 binding modulators for the treatment of ocular disorders, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pai-1 binding modulators for the treatment of ocular disorders will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1482445