Pai-2 and t-pa as diagnostic markers of periodontal disease

Details Pai-2 and t-pa as diagnostic markers of periodontal disease Pai-2 and t-pa as diagnostic markers of periodontal disease

G - Physics

01

N

G01N 33/573 (2006.01) C12Q 1/37 (2006.01) G01N 33/86 (2006.01)

Patent

CA 2318740

The existence and the extent of periodontal disease can be diagnosed by measuring plasminogen activator inhibitor 2 (PAI-2) and/or tissue plasminogen activator (t-PA) levels in gingival crevicular fluid (GCF). Levels of PAI-2 and t-PA in GCF rise sharply in the context of periodontal disease, and they also correlate with the severity of disease at different sites in the same patient.

Selon cette invention, il est possible de diagnostiquer l'existence et l'étendue de la parodontopathie en mesurant les taux d'inhibiteurs 2 (PAI-2) de l'activateur du plasminogène et/ou de l'activateur (t-PA) du plasminogène de type tissulaire dans le fluide gingival. L'augmentation brusque des taux de PAI-2 et t-PA dans le fluide gingival indiquent la présence de la parodontopathie, ces taux ayant également une corrélation avec la gravité de la maladie au niveau de différents sites chez le même patient.

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