Pain reducing parenteral liposome formulation

Details Pain reducing parenteral liposome formulation Pain reducing parenteral liposome formulation

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 31/70 (2006.01)

Patent

CA 2279259

Disclosed is an invention directed towards pain-reducing parenteral formulations comprising a macrolide drug entrapped in a liposome vesicle. The macrolide drug is selected from the group consisting of derivatives of erythromycins A, B, C and D; clarithromycin; azithromycin; dirithromycin; josamycin; midecamycin; kitasamycin; roxithromycin; rokitamycin; oleandomycin; miocamycin; flurithromycin; rosaramicin; 8,9-anhydro-4''-deoxy-3'-N-desmethyl- 3'-N-ethylerythromycin B 6,9-hemiacetal; 8,9-anhydro-4''-deoxy-3'-N-desmethyl- 3'-N-ethylerythromycin A 6,9-hemiacetal; and 11-amino-11-deoxy-3-oxo-5-O- desosaminyl-6-O-[1'-3'-quinolyl-2'-propenyl]-erythronolide A 11,12-cyclic carbamate. The formulations of the invention are effective in substantially reducing the pain at the injection site typically associated with the injection of macrolide antibiotics.

Cette invention a trait à des formulations à administration parentérale analgésiques comprenant un macrolide enfermé dans un liposome. Le macrolide est issu du groupe constitué par des dérivés d'érythromycines A, B, C et D, la clarithromycine, l'azithromycine, la dirithromycine, la josamycine, la midécamycine, la kitasamycine, la roxithromycine, la rokitamycine, l'oléandomycine, la miocamycine, la flurithromycine, la rosaramycine ainsi que par 8,9-anhydro-4''-désoxy-3'-N-desméthyl-3'-N-éthylérythromycine B 6,9-hémi-acétal, 8,9-anhydro-4''-désoxy-3'-N-desméthyl-3'-N-éthylérythromycine B 6,9-hémi-acétal et 11-amino-11-désoxy-3-oxo-5-O-désosaminyl-6-O-[1'-3'-quinolyl-2'-propényl]-érythronolide A 11,12-carbamate cyclique. Les formulations de l'invention soulagent efficacement les douleurs sur le site d'injection, d'ordinaire en association avec une injections d'antibiotiques consistant en des macrolides.

Affiliated with

Also associated with

Rating

Pain reducing parenteral liposome formulation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pain reducing parenteral liposome formulation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pain reducing parenteral liposome formulation will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1374269