Pain signaling molecules

Details Pain signaling molecules Pain signaling molecules

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) G01N 33/543 (2006.01) G01N 33/566 (2006.01) G01N 33/567 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2486538

The invention relates generally to a human MrgD polypeptide, one of a family of recently identified G protein coupled receptors (Figure 6B) that are involved in pain sensation. Particular methods are provided for identifying agonists and antagonist of human MrgD, along with methods of utilizing the agonists and antagonists in modifying the perception of pain.

L'invention concerne, d'une manière générale, un polypeptide MrgD humain, constituant un membre d'une famille de récepteurs couplés aux protéines G récemment identifiées (Figure) lesquels sont impliqués dans la sensation de douleur. L'invention concerne notamment des procédés d'identification d'agonistes et d'antagonistes de MrgD humain, ainsi que des procédés d'utilisation des agonistes et antagonistes pour modifier la perception de la douleur.

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