Pain signaling molecules

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61P 25/04 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 15/10 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2407219

The invention relates generally to novel genes expressed in normal but not Neurogenin-1-deficient animals. The invention relates specifically to a novel family of G protein-coupled receptors and a novel family of two-transmembrane segment proteins that are expressed in dorsal root ganglia, and a method of screening for genes specifically expressed in nociceptive sensory neurons.

Cette invention se rapporte de manière générale à de nouveaux gènes exprimés dans des animaux normaux mais ne présentant pas de déficit en neurogénine 1. Dans un aspect plus spécifique, cette invention concerne une nouvelle famille de récepteurs couplés à la protéine G et une nouvelle famille de protéines à deux segments transmembranaires qui sont exprimées dans les ganglions spinaux, ainsi qu'un procédé permettant l'identification de gènes exprimés de manière spécifique dans les neurones sensoriels nociceptifs.

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