A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2747206
The present invention relates generally to a method for the treatment and prophylaxis of pain. In accordance with the present invention, it is proposed that antagonists of GM-CSF are effective in the treatment of pain. Antagonists of GM-CSF include, but are not limited to, antibodies which are specific for GM-CSF or the GM-CSF receptor. The present invention further provides transgenic animals, such as a GM-CSF knock-out mouse, useful for testing antagonists in certain disease models.
L'invention porte d'une manière générale sur une méthode de traitement et de prévention de la douleur. Selon l'invention, les antagonistes du GM-CSF sont efficaces pour le traitement de la douleur. Les antagonistes du GM-CSF comprennent notamment, mais non exclusivement, des anticorps spécifiques contre le GM-CSF ou le récepteur du GM-CSF. L'invention porte en outre sur des animaux transgéniques tels qu'une souris knock-out à déficience GM-CSF, utilisés pour tester des antagonistes dans certains modèles de maladies.
Cook Andrew David
Hamilton John Allan
Borden Ladner Gervais Llp
The University Of Melbourne
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