Painkilling association comprising a dihydroimidazopyrazine...

Details Painkilling association comprising a dihydroimidazopyrazine... Painkilling association comprising a dihydroimidazopyrazine...

A - Human Necessities

61

K

A61K 45/06 (2006.01) A61K 31/4985 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2591217

The invention relates to a product comprising (1R)-1-[({(2R)-2-amino-3-[(8S)-8-(cycloliexylmethyl)-2-phenyl-5,6-dihydroimidazo [1,2-a]pyrazin-7(8H)-yl]-3-oxopropyl}dithio)methyl]-2-[(8S)-8-(cyclohexylmethyl)-2-phenyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl]-2-oxoethylamine in association with an analgesic agent selected form morphine, the similar or a morphine derivative, sodium channel inhibitors, non-steroidal antiflammatory agents (AINS), glutamatergic system inhibitors, tricycle antidepressants and gabaergic derivatives for simultaneous therapeutic use which is separated or spread out over the time for pain treatment or prevention.

L'invention offre aussi un produit comprenant du (1R)-l-[({(2R)-2-amino-3- [(8)S)-8-(cycloliexylméthyl)-2-phényl-5,6-dihydroimidazo [1,2-a]pyrazin-7(8H)- yl]-3-oxopropyl}dithio)méthyl]-2-[(8S)-8-(cyclohexylméthyl)-2-phényl-5,6- dihydroimidazo[1,2-a]pyrazin-7(8H)-yl]-2-oxoéthylamine en association avec un agent analgésique choisi parmi la morphine, un analogue ou dérivé de la morphine, les inhibiteurs des canaux sodiques, les anti-inflammatoires non stéroïdiens (AINS), les inhibiteurs du système glutamatergique, les antidépresseurs tricycliques et les dérivés gabaergiques pour une utilisation thérapeutique simultanée, séparée ou étalée dans le temps dans le traitement ou la prévention de la douleur.

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