C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 401/00 (2006.01) C07B 37/10 (2006.01) C07C 17/26 (2006.01) C07C 22/00 (2006.01) C07C 33/44 (2006.01) C07C 35/21 (2006.01) C07F 7/08 (2006.01) C07F 7/18 (2006.01)
Patent
CA 2129136
2129136 9316022 PCTABS00025 An alkylative cycloaddition method is provided that is particularly useful for the synthesis of many of the Vitamin D analogues with differing side chains. Thus, a preferred synthesis is of Vitamin D analogues having a side chain R1 where a substantially geometrically pure first precursor having structure (I), and a second precursor are provided, the second precursor being a 1,7 enyne. These precursors are reacted in the presence of a palladium catalyst to form compounds having structure (II), where R2 is hydrogen, hydroxyl, lower alkoxy, fluorine, or a protecting group, and R3 is hydrogen, hydroxyl, lower alkoxy, fluorine, or a protecting group.
Dumas Jacques
Trost Barry M.
Board Of Trustees Of The Leland Stanford Junior University (the)
Ridout & Maybee Llp
LandOfFree
Palladium catalyzed alkylative cyclization useful in... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Palladium catalyzed alkylative cyclization useful in..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Palladium catalyzed alkylative cyclization useful in... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1818300