Pancreas-derived serpin

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/15 (2006.01) A61K 31/70 (2006.01) C07H 21/00 (2006.01) C07K 14/81 (2006.01) C07K 16/38 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2218034

The present invention provides nucleotide and amino acid sequences that identify and encode a novel Pancreas-Derived Serpin (PDS) expressed in human pancreas. The present invention also provides for antisense molecules to the nucleotide sequences which encode PDS, expression vectors for the production of purified PDS, antibodies capable of binding specifically to PDS, hybridization probes or oligonucleotides for the detection of PDS-encoding nucleotide sequences, genetically engineered host cells for the expression of PDS, diagnostic tests based on PDS-encoding nucleic acid molecules and a pharmaceutical composition containing PDS capable of binding specifically to a serine protease.

L'invention porte sur un nucléotide et des séquences d'aminoacides qui identifient et codent une nouvelle serpine dérivée du pancréas (PDS) exprimée dans le pancréas humain. L'invention concerne également des molécules anti-sens vis-à-vis des séquences nucléotidiques codant une PDS, des vecteurs d'expression pour la production de PDS purifiée, des anticorps capables de se lier de manière spécifique à une PDS, des sondes d'hybridation ou des oligonucléotides aux fins de la détection de séquences nucléotidiques codant une PDS, des cellules hôtes obtenues par génie génétique pour l'expression de PDS, des tests diagnostiques fondés sur des molécules d'acide nucléique codant une PDS et une composition pharmaceutique contenant une PDS capable de se lier de manière spécifique à une serine protéase.

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