C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/18 (2006.01) C07K 16/40 (2006.01) C12N 9/66 (2006.01) G01N 33/573 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2088354
A process is described for obtaining highly specific pancreas elastase 1 antibodies which react both with bodily fluids and with stools. Such an antibody is obtainable by immunizing with an antigen having the amino acid sequence Thr-Met-vat-Ala-Gly-Gly-Asp- Ile-Arg or immunologically active partial peptides thereof. A test kit containing such antibodies is suitable for the diagnosis and course monitoring of chronic and acute pancreatitis as well as mucovisoidosis in bodily fluids and/or in stools.
Il est décrit un procédé pour l'obtention d'un anticorps hautement spécifique à la pancréas-élastase 1, lequel réagit aussi bien avec les substances liquides du corps qu'avec les selles. Un tel anticorps peut être obtenu par l'immunisation au moyen d'un antigène présentant une séquence d'acides aminés Thr-Met-Val-Ala-Gly-Gly-Asp-Ile-Arg ou bien des peptides partiels à action immunologique qui en font partie. Un kit de test contenant de tels anticorps se prête au diagnostic et à la surveillance, dans les substances liquides du corps et/ou dans les selles, de la pancréatite chronique et aiguee, ainsi que de la mucoviscidose.
Scheefers Hans
Scheefers-Borchel Ursula
Sziegoleit Andreas
Gowling Lafleur Henderson Llp
Schebo-Tech Gmbh
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