C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/071 (2010.01) C12N 5/0735 (2010.01) A61K 35/39 (2006.01) A61P 3/10 (2006.01) C12N 5/10 (2006.01) C12N 15/87 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2723820
The invention provides pluripotent cells modified to overexpress Pdx1 and Ngn3. Pluripotent cells include embryonic stem cells and induced pluripotent stem cells. Methods of producing pancreatic endocrine progenitor cells from ES cells or from iPS cells by forced expression of Pdx1 and Ngn3 are provided. Pancreatic endocrine progenitor cells are useful for drug discovery and cell replacement therapy.
La présente invention concerne des cellules pluripotentes modifiées pour surexprimer Pdx1 et Ngn3. Ces cellules pluripotentes comprennent des cellules souches embryonnaires (ES) et des cellules souches pluripotentes induites (iPS). L'invention concerne également des procédés de production de cellules progénitrices endocrines pancréatiques à partir de cellules ES ou iPS grâce à l'expression forcée de Pdx1 et Ngn3. Les cellules progénitrices endocrines pancréatiques se révèlent utiles pour la découverte de nouveaux médicaments et pour des thérapies impliquant un remplacement cellulaire.
Bonham Kristina
Kubo Atsushi
Snodgrass H. Ralph
Stull Robert
Borden Ladner Gervais Llp
Vistagen Therapeutics Inc.
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