Pancreatic islet cell antigens obtained by molecular cloning

Details Pancreatic islet cell antigens obtained by molecular cloning Pancreatic islet cell antigens obtained by molecular cloning

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 5/04 (2006.01) C07K 7/04 (2006.01) C07K 14/705 (2006.01) C12N 1/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2010275

Pancreatic islet cell antigens (ICA) that bind with antibodies found in the sera of patients afflicted with insulin-dependent (Type I) diabetes mellitus (IDDM). ICA proteins are expressed by recombinant cloning vehicles comprising DNA inserts isolated from islet cells. Full sequence native ICA proteins, or protein or peptide fragments thereof, can be used in the diagnosis of IDDM and in detecting or blocking human immunoglobulin, T-cells, or B-cells involved in IDDM.

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