C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/575 (2006.01) C07K 14/435 (2006.01) C07K 14/46 (2006.01)
Patent
CA 2555894
The present invention relates to novel Pancreatic Polypeptide Family ("PPF") polypeptides. The PPF polypeptides of the invention generally include at least two PPF motif, have at least 50 % sequence identity to PYY (3-36) over its length and will generally retain, at least in part, a biological activity of a PP, PYY or NPY. Preferred PPF polypeptides of the invention are those having a potency in one of the assays described herein (preferably food intake, gastric emptying, pancreatic secretion, or weight reduction assays) which is greater than the potency of PP, NPY, PYY, or PYY(3-36) in that same assay. In one aspect, the PPF polypeptides of the invention include novel PYY analog polypeptides. In another aspect, the PPF polypeptides of the invention include PPF chimeric polypeptides including a fragment of a PP family polypeptide linked to a second PP family polypeptide, wherein each of the first and second fragments includes a PPF motif. Methods of using the PPF polypeptides of the invention, and pharmaceutical compositions including the PPF polypeptides of the invention are also disclosed.
La présente invention concerne des nouveaux polypeptides de la <=Famille des polypeptides pancréatiques >= (Pancreatic PolypeptideFamily/PPF). Les polypeptides PPF de l'invention comprennent généralement au moins deux motifs PPF, présentent une identité de séquence d'au moins 50 % avec PYY (3-36) sur toute sa longueur et conservent, au moins en partie, une activité biologique de PP, PYY ou NPY. Les polypeptides PPF préférés de l'invention sont ceux dont la puissance manifestée dans l'un des essais décrits (de préférence prise de nourriture, vidange gastrique ou essai de perte de poids) est supérieure à celle de PP, NPY, PYY, ou PYY(3-36) dans le même essai. Selon un aspect, les polypeptides PPF de l'invention comprennent des nouveaux polypeptides PYY analogues. Selon un autre aspect, ils comprennent des polypeptides PPF chimères dont un fragment de d'un polypeptides de la famille PP est lié à un second fragment de la famille PP, chacun des premier et second fragments incluant un motif PPF. Sont également décrites des méthodes d'utilisation des polypeptides PPF de l'invention ainsi que des compositions pharmaceutiques contenant lesdits polypeptides PPF.
Ahn John S.
D'souza Lawrence J.
Ghosh Soumitra S.
Jodka Carolyn M.
Levy Odile Esther
Amylin Pharmaceuticals Inc.
Smart & Biggar
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