C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/4439 (2006.01)
Patent
CA 2607583
The invention relates, in general, to a new solid crystalline form of pantoprazole free acid (denominated "Form III"), salts derived therefrom (e.g., pantoprazole sodium and pantoprazole sodium sesquihydrate) and methods for producing the same. The invention further includes formulating pantoprazole free acid Form III, salts derived therefrom (e.g., pantoprazole sodium and pantoprazole sodium sesquihydrate) and/or in vivo cleavable prodrugs thereof (collectively "the compounds of the invention") into readily usable dosage units for the therapeutic treatment (including prophylactic treatment) of mammals, including humans.
L'invention se rapporte de manière générale à une nouvelle forme cristalline solide d'acide libre de pantoprazole (dénommée "forme III"), aux sels dérivés de celle-ci, (p. ex. pantoprazole sodique et pantoprazole sodique sesquihydraté) et à des procédés permettant de produire ceux-ci. L'invention concerne en outre la préparation d'acide libre de pantoprazole de forme III, des sels dérivés de ceux-ci (p. ex. pantoprazole sodique et pantoprazole sodique sesquihydraté), et de promédicaments clivables in vivo de ceux-ci (désignés collectivement comme "composés faisant l'objet de l'invention") sous forme d'unités posologiques prêtes à l'emploi, pour le traitement thérapeutique (y compris le traitement préventif) des mammifères, y compris de l'homme.
Medichem S.a.
Smart & Biggar
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