Papaya mosaic virus-based vaccines for influenza

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/62 (2006.01) A61K 39/12 (2006.01) A61K 39/145 (2006.01) A61K 39/295 (2006.01) A61K 39/39 (2006.01) A61K 47/48 (2006.01) A61P 31/16 (2006.01) A61P 37/04 (2006.01) C07K 14/08 (2006.01) C07K 14/11 (2006.01) C07K 19/00 (2006.01) C12N 7/01 (2006.01) C12N 15/40 (2006.01) C12N 15/44 (2006.01)

Patent

CA 2669485

An antigen-presenting system (APS) comprising one or more antigens in combination with a papaya mosaic virus (PapMV) or a virus like particle (VLP) derived from papaya mosaic virus is provided. Specifically an APS comprising one or more influenza virus antigens is provided. The APS can be used, for example, as a vaccine against influenza. The one or more antigens comprised by the APS can be conjugated to a coat protein of the PapMV or PaPMV VLP, or they may be non-conjugated (i.e. separate from the PapMV or PapMV VLP). Conjugation can be, for example, by genetic fusion with the coat protein, or binding via covalent, non-covalent or affinity means.

L'invention concerne un système présentant des antigènes (APS) qui comprend un ou plusieurs antigènes combinés au virus de la mosaïque du papayer (PapMV) ou une particule de type virus (VLP) dérivée du virus de la mosaïque du papayer. Cet APS peut être utilisé, par exemple, en tant que vaccin contre la grippe. Le ou les antigènes contenus dans l'APS peuvent être conjugués à une protéine de revêtement de PapMV ou PapMV VLP, ou non (par ex. séparé du PapMV ou du PapMv VLP). La conjugaison peut être, par exemple, une fusion génétique avec la protéine de revêtement, ou une liaison par l'intermédiaire de moyens d'affinité, de moyens covalents ou de moyens non covalents.

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