Papillomavirus: biosynthetic process and assays

Details Papillomavirus: biosynthetic process and assays Papillomavirus: biosynthetic process and assays

C - Chemistry, Metallurgy

12

N

C12N 7/04 (2006.01) A61K 39/12 (2006.01) C12N 5/00 (2006.01) C12N 5/06 (2006.01) C12N 7/02 (2006.01) C12Q 1/70 (2006.01) G01N 33/50 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2142469

The present invention provides a process of biosynthesizing papillomavirus by inducting complete differentiation of an ep- ithelial cell that contains papillomavirus DNA. Complete differentiation is induced by exposing epithelial cells to a protein ki- nase C inducer. Assays for screening agents that modify papillomavirus biosynthesis, determining the papillomavirus infectivity of epithelial cells, detecting the presence of anti-papillomavirus antibodies and vaccinating against papillomavirus infection are also provided.

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