Papillomavirus vaccine

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/86 (2006.01) A61K 39/12 (2006.01) C07K 14/025 (2006.01) C12N 7/04 (2006.01) C12N 15/863 (2006.01)

Patent

CA 2675355

The present invention relates to the use of a nucleic acid molecule encoding at least one papillomavirus E2 polypeptide, or a vector, an infectious viral particle or a composition thereof for the preparation of a drug intended for treating a patient suffering from a persistent papillomavirus infection caused by at least one papillomavirus. The present invention also provides a vector comprising a nucleic acid molecule comprising a first nucleotide sequence encoding a papillomavirus E1 polypeptide and a second nucleotide sequence encoding a papillomavirus E2 polypeptide wherein the 3' portion of the first nucleotide which in the natural context is 100% identical to the 5' portion of the second nucleotide is modified so as to exhibit a percentage of identity between said portions of at most 75%.

L'invention concerne l'utilisation d'une molécule d'acide nucléique codant au moins un polypeptide E2 de papillomavirus, ou un vecteur, une particule virale infectieuse ou une composition de celui-ci, dans la préparation d'un médicament destiné à traiter un patient souffrant d'une infection persistante à papillomavirus causée par au moins un papillomavirus. L'invention concerne également un vecteur comprenant une molécule d'acide nucléique comprenant une première séquence nucléotidique codant un polypeptide E1 de papillomavirus et une seconde séquence nucléotidique codant un polypeptide E2 de papillomavirus, la partie 3' du premier nucléotide qui, dans son contexte naturel est identique à 100 % à la partie 5' du second nucléotide étant modifiée de sorte à présenter un pourcentage d'identité inférieur à 75 % entre lesdites parties.

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