Papillomavirus vaccine compositions

Details Papillomavirus vaccine compositions Papillomavirus vaccine compositions

A - Human Necessities

61

K

A61K 39/12 (2006.01)

Patent

CA 2679720

The present invention relates to pharmaceutical compositions comprising virus-like particles (VLPs) of HPV, said VLPs adsorbed to an aluminum adjuvant, and an ISCOM-type adjuvant comprising a saponin, cholesterol, and a phospholipid. In preferred embodiments, the aluminum adjuvant comprises amorphous aluminum hydroxyphosphate sulfate. Another aspect of the invention provides multi-dose HPV vaccine formulations comprising HPV VLPs and an antimicrobial preservative selected from the group consisting of: m-cresol, phenol and benzyl alcohol. Also provided are methods of using the disclosed pharmaceutical compositions and formulations to induce an immune response against HPV in a human patient and to prevent HPV infection.

L'invention concerne des compositions pharmaceutiques comprenant des particules analogues à un virus (VLP) de HPV, les VLP étant adsorbées sur un adjuvant d'aluminium, et un adjuvant du type ISCOM comprenant une saponine, du cholestérol, et un phospholipide. Dans des modes préférés de réalisation, l'adjuvant aluminium comprend du sulfate d'hydroxyphosphate d'aluminium amorphe. L'invention concerne également des formulations de vaccin HPV multidoses comprenant des VLP de HPV et un conservateur antimicrobien sélectionné dans le groupe constitué de : M-crésol, phénol et alcool benzylique. L'invention concerne également des procédés d'utilisation des compositions pharmaceutiques décrites et des formulations qui doivent induire une réponse immunitaire contre le HPV chez un patient humain et prévenir l'infection par le HPV.

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