Papsss as modifiers of the axin pathway and methods of use

Details Papsss as modifiers of the axin pathway and methods of use Papsss as modifiers of the axin pathway and methods of use

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07K 14/47 (2006.01) C12Q 1/00 (2006.01) C12Q 1/48 (2006.01) G01N 33/53 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2493752

Human PAPSS genes are identified as modulators of the AXIN pathway, and thus are therapeutic targets for disorders associated with defective AXIN function. Methods for identifying modulators of AXIN, comprising screening for agents that modulate the activity of PAPSS are provided.

Des gènes PAPSS humains sont identifiés comme modulateurs de la voie d'AXIN, et constituent ainsi des cibles thérapeutiques pour des troubles associés à une fonction déficiente d'AXIN. L'invention concerne des procédés d'identification de modulateurs d'AXIN, qui comprennent le criblage d'agents modulant l'activité de PAPSS.

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